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Why we created GS441524 with vitamin B12 for the treatment of Feline Infectious Peritonitis (FIP)

Updated: Jan 25, 2022

*Concentration of GS-441524: 20mg/ml

**Concentration of Vitamin B12: 50mcg/ml

Benefit of Vitamin B12

B12 promotes red cell synthesis (the development and maintenance of red blood cells). Adequate levels of B12 are required to prevent anemia.

B12 maintains nervous system integrity (nerve cells and normal myelination –the fatty sheaths that cover and protect nerve endings). It is essential for nerve and cognitive functions.

B12 promotes intestinal health for better digestion and absorption of food, as well as the metabolism of carbohydrates and fats.

10 Signs of B12 deficiency

  1. Nausea

  2. Vomiting

  3. Loss of appetite

  4. Poor absorption of food

  5. Constipation

  6. Gas

  7. Weight Loss

  8. Fatigue/ Lethargy

  9. Abdominal Pain

  10. Diarrhea

Recommended Weekly Dosage of Vitamin B12 During FIP Treatment

For non-anemic adult cats, up to 250-500 microgram (mcg) every weeks.

For kittens, please consult your veterinarian for appropriate dosage.

For cats with severe anaemia up to 1000 mcg per week may be needed. In the case of severe anemia, GS-441524 with Vitamin B12 alone may not be sufficient. Additional weekly vitamin B12 injection may be necessary. Consult your veterinarian.

Dosage calculation when using GS-441524 + B12

The dosage is same for GS-441524 with or without vitamin B12. Example: Cat diagnosed with WET form of FIP and is currently weighing 3kg. Recommended dosage for wet form of FIP is 6mg/kg. 3 kg x 6 mg/kg ÷ 20 mg/ml = 0.9 ml of GS-441524 daily injection. Daily intake of vitamin B12: 0.9ml x 50mcg/ml = 45mcg daily dosage. Weekly, this cat will be receiving 315 mcg of vitamin B12

Why Cats with FIP need Vitamin B12

High risk of anemia.

Cats often become anemic during Feline Infectious Peritonitis (FIP) infection. B12 deficiency inhibits and decreases the body's natural ability to produce new blood and accelerates blood cell destruction. When B12 level plunges, cats become anemic. Once cats become anemic, its ability to fight the FIP virus and other diseases decreases considerably.

Weakened immune system.

Insufficient B12 in the body raises susceptibility to infections and diseases, and is very harmful to cat's nervous system, in turn leads to faster onset of neurological symptoms, and severe or irreversible nervous system damages. B12 deficiency is a common cause of metabolic encephalopathy, one of a number of forms of encephalopathy associated with a primary disease (such as FIP) that causes interference with normal brain functions and blood-brain barrier mechanisms. Clinical signs are indistinct and include lethargy, depression, ataxia, anorexia and intermittent vomiting, and in severe cases, can induce neurological disease and blindness in cats.

It is well documented that cats infected by FIPV are often anemic or borderline anemic. Many exhibit neurological symptoms. This is a classical negative feedback loop: without appropriate levels of B12, FIP infection worsens more rapidly. Because of FIP, cat's ability to retain adequate B12 in the body is diminished.

Rapid depletion of nutrients When a cat is diagnosed with FIP, several functions of the body such as liver, GI (gastrointestinal) tract, pancreas and spleen may be affected since FIP is an inflammatory disease. When the immune system is weakened, the liver depletes B12 reserves speedily. Intestinal cells shrinking and malabsorption nutrients will happen when B12 is insufficient in the liver. When this happens, it will lead to a cycle of even more severe B12 deficiency.

Our newest GS-441524 + B12 breaks this negative loop by stopping the FIP viral replication and provides additional B12 to the body to increase its natural resistance to the virus.

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